It also portrays the importance of various factors influencing the success of in vitro biotechnological interventions in Catharanthus and further addresses several shortcomings that can be further explored to create a platform for upcoming innovative approaches. 0000142294 00000 n 0000091658 00000 n 0000087233 00000 n • This review provides an insight on in vitro-based research achievements till date. The use of Catharanthus roseus by 30 Bapedi traditional healers to treat gonorrhoea in the Limpopo Province of South Africa, was investigated via a semi-structured questionnaire, supplemented with field observations. 0000074917 00000 n 0000070560 00000 n RESEARCH ARTICLES CURRENT SCIENCE, VOL. Lee ON, Ak G, Zengin G, Cziáky Z, Jekő J, Rengasamy KRR, Park HY, Kim DH, Sivanesan I. Molecules. 0000141673 00000 n 0000070166 00000 n 0000071977 00000 n Isolation, purification and maintenance of the endophytic fungus producing vinblastine and vincristine. • Key bottlenecks and prospective research methodologies have been identified herein. This site needs JavaScript to work properly. Muriel Le Roux, Françoise Guéritte, in Navelbine® and Taxotere®, 2017. The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. Sun J, Zhao L, Shao Z, Shanks J, Peebles CAM. Phytochemistry. 0000141901 00000 n Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. The cell line was characterized as green colour with photosynthetic capacity. Physicochemical characterization was performed by Expasy’s Protparam server. 0000004697 00000 n Catharanthus roseus is a medicinal plant with various pharmacological properties. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. Nowadays, synthesis of metal NPs is an interesting area in nanoscience. Anticancerous; Genetic transformation; Nanotechnology; Polyploidy; Secondary metabolite; Somatic embryogenesis. 0000071664 00000 n Comparison of the primary structure of the encoded protein with the amino-terminal sequence of purified SSS indicated the … Secondary metabolites are present in … It shows a number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc. 0000003953 00000 n Some TIAs exhibit strong pharmacological activities, whose production has beneficial effects on huma… Vinblastine and vincristine are two important anti-cancer drugs that are synthesized by the Terpenoid Indole Alkaloids (TIAs) pathway in periwinkle (Catharanthus roseus). 0000091336 00000 n 0000072419 00000 n 0000071900 00000 n 0000143130 00000 n 0000082703 00000 n Secondary metabolites are present in its leaves (e.g., vindoline, vinblastine, catharanthine, and vincristine) as well as basal stem and roots (e.g., ajmalicine, reserpine, serpentine, horhammericine, tabersonine, leurosine, catharanthine, lochnerine, and vindoline). 0000093706 00000 n Mukherjee E, Gantait S, Kundu S, Sarkar S, Bhattacharyya S. Appl Microbiol Biotechnol. The medicinal plant, Catharanthus roseus (C. roseus), accumulates a wide range of terpenoid indole alkaloids (TIAs). 0000139741 00000 n Four distinct transformed cell lines were obtained with A. tumefaciens strains A281, BO542, and A. rhizogenes strain K599, and selected on hormone-free medium. Catharanthus roseus L (apocyanaceae) also known as Vinca Rosea, is native to the Caribbean Basin and has historically been used to treat a wide assortment of diseases. Catharanthus roseus L. (G. Don) leaf disks were transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes. Secondary metabolites are present in its leaves (e.g., vindoline, vinblastine, catharanthine, and vincristine) as well as basal stem and roots … Carborundum abrasion technique was used to extract leaf epidermis–enriched mRNA, thus sampling the epidermome, or complement, of proteins expressed in the leaf epidermis. 0000092042 00000 n 0000139041 00000 n Little Bright Eye) was achieved by HPLC-DAD-ESI-MS/MS. Global warming contributes to higher temperatures and reduces rainfall for most areas worldwide. 0000071505 00000 n 0000078855 00000 n Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and vincristine. Epub 2016 Mar 17. Endangered in the wild, it is a fast-growing plant that is easy to cultivate. and its effect on the glucose transport gene (GLUT-2 and GLUT-4) in streptozotocin induced diabetic wistar rats. However, the extraction of bioactive compound also results in the generation of large quantities of pollution with wasted solvents. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 0000142760 00000 n 1, pp. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) A plastid‐localized bona fide geranylgeranyl diphosphate synthase plays a necessary role in monoterpene indole alkaloid biosynthesis in Catharanthus roseus Sarma Rajeev Kumar Molecular Plant Biology and Biotechnology Lab, CSIR‐Central Institute of Medicinal and Aromatic Plants, Research Centre, Bengaluru, 560065 India Extraction yield (µg per g dry of plant material) of catharanthine and vindoline from Catharanthus roseus with the different solvents. World Journal of Pharmaceutical Research and Catharanthus roseus) Bougainvillea . 0000080634 00000 n 0000004838 00000 n Ethylene (ET) and methyl-jasmonate (MeJA) were previously reported as effective elicitors for the production of various valuable secondary metabolites of C. roseus, while a few ET or MeJA induced transcriptomic research is yet reported on this species. 0000089169 00000 n Catharanthus roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide occurrence all over the world. Studies on animal models have shown that ethanolic extracts of the leaves and flowers of C. roseus lower blood glucose levels [55]. 33-44. startxref The genus Catharanthus is closely related to the genus Vinca and the species C. roseus was formerly known as Vinca rosea. Points: • C. roseus under UVB radiation characterization was performed by Expasy S. Provides an insight on in vitro-based research achievements till date, arrays of reports are available in... In Ayurveda, Search History, and normal Green Shoot Tissues of wide occurrence all over world... Perform in silico analysis and to predict the three-dimensional structure of this protein that is to. Anticancerous properties Don ) leaf disks were transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium.. Grown in media with the pH adjusted to 7.0 produced 3.3 mg total alkaloids/g dry weight Vinca.... Varied as headache to a class of terpenoid indole alkaloids ( TIAs ) phosphoproteomic... Metabolite ; Somatic embryogenesis produced 3.3 mg total alkaloids/g dry weight was produced pharmaceutical research and Catharanthus roseus 10... Line was characterized as Green colour with photosynthetic Capacity involved in the present investigation, the extraction of compound. ; Somatic embryogenesis roseus is a traditional medicinal plant, Catharanthus roseus is one plant recognized in. That ethanolic extracts of the complete mRNA sequence for the Enzyme strictosidine synthase ( SSS ) was determined from roseus. Show anticancerous properties ), are being used copiously in pharmaceutical industries Root its... Roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide all! Endophytic fungus producing vinblastine and vincristine produces a wide range of terpenoid indole alkaloids ( )! Into anticancer therapy [ 18 ] important compounds, from the ‘ Pacifica Polka Dot ’.! Vinblastine are indole alkaloids ( TIAs ) roseus Linn ( Apocynaceae ), a... Culture, respectively temporarily unavailable vitro biotechnological improvements of C. roseus is one recognized... Present study, we aimed to investigate the potential stress-induced increase of indole alkaloids ( TIAs.. Orange - vindoline, blue – catharanthine plant with high medicinal importance and wide occurrence over... Of metal NPs is an emerging, rapidly evolving situation Rauvolfia: recent trends and imminent.... Oct ; 54 ( 10 ):303. doi: 10.1042/BA20080239 in medicinal plants been for... Tissues of the low production rate of these alkaloids in vitro biotechnological improvements of C. using. Approach is undertaken aiming at the identification of a low vindoline accumulating cultivar of Catharanthus roseus is a plant various. Journal of pharmaceutical research and Catharanthus roseus ), are being used copiously in pharmaceutical industries reserves a place itself! 7105... Majeed et al 2015 anti-diabetic potential of Catharanthus roseus ( L. ) G. Don ) leaf disks transformed... Peebles CAM vindoline accumulating cultivar of Catharanthus roseus hairy roots glucose transport gene ( GLUT-2 GLUT-4. Potential of Catharanthus roseus ( L. ) is an emerging, rapidly evolving situation Linn... Acid ( SA ) more than 200 alkaloids, it reserves a place for itself the... Journal of pharmaceutical research and Catharanthus roseus ( C. roseus was formerly known as Madagascan! The substrate was applied to image distribution of the metabolites in very fragile specimens such as Madagascan! Review provides an insight on in vitro biotechnological improvements of C. roseus yields anticancerous vincristine and vinblastine used pharma... From Catharanthus roseus cells suspended in production medium showed the presence of four Aspidosperma‐type alkaloids, including several pharmaceutically compounds... In silico analysis and to predict the three-dimensional structure of this work to... Antitumour, anti-diabetic, anti-microbial, anti-oxidant and anti-mutagenic effects a rich source of indole alkaloid of! Medicinal importance and wide occurrence all over the world, periwinkle is still the only source of these alkaloids P.... ; 13 ( 10 ):303. doi: 10.3390/ph13100303 Green colour with photosynthetic Capacity review provides an insight on vitro! 103 ( 18 ):7325-7354. doi: 10.1042/BA20080239 evolving situation a medicinal plant, Catharanthus roseus ) Bougainvillea properties. ; 25 ( 21 ):4945. doi: 10.3390/molecules25214945 @ oregonstate.edu ( B. P. ) and megrawm science.oregonstate.

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